Published: 6 February, 2018
Global regulatory consultants, Yordas Group have taken the lead on the Stakeholder Engagement and Dissemination Work package for the H2020 GRACIOUS Project, which kicked-off in January 2018.
The GRACIOUS project will develop a highly innovative science based framework that supports the assessment of risk posed by the ever increasing array of nanomaterials on the market and under development. The framework will streamline the process for assessing their risk by logically grouping nanomaterials thereby allowing extrapolation between (read-across) nanomaterials and reducing the need to assess exposure to and toxicity on a case by case basis.
Yordas attended the project kick-off meeting, which was held in Edinburgh, UK on 22-23 January 2018, where members of the consortium discussed how the project goal was to be achieved and how to involve key partners in small, medium and large scale industries, as well as national and international policy makers and regulators.
Industry has the ability to modify the chemical and physical characteristics of materials at the nanoscale leading to a wide array of nanomaterials (NMs) varying in size, morphology and surface characteristics. Due to financial, time and ethical considerations, safety testing of every unique NM for their potential adverse effects is virtually impossible. For these reasons, more efficient ways to obtain safety information are needed. Yordas, along with 22 partners spanning Europe and the USA, are involved in developing the GRACIOUS framework which aims to account for those issues with the ultimate aim of streamlining the risk assessment process.
Underpinned by scientific hypotheses, the GRACIOUS framework will identify endpoints relevant to grouping and read-across. To generate the knowledge and data needed to identify and test these hypotheses Intelligent Testing Strategies (ITSs) will be developed to cover all domains of relevance for risk assessment:
The ITSs will reduce, refine and replace (where possible) the need for animal testing by promoting the use of modelling (e.g. in silico, fate, exposure), in vitro and cell-free tests.
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